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KMID : 0882419930440060760
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Korean Journal of Medicine
1993 Volume.44 No. 6 p.760 ~ p.765
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Effetc of Blood Pressure Control on Progression Rate of Renal Function in Patients with diabetic Renal Insufficiency
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박인석
박주현/이승헌/안석주/양철우/김석영/장윤식/윤영석/존호영
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Abstract
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ackground : Diabetic nephropathy is considered as the main cause of end stage renal
disease which needs the renal replacement therapy. The adequate control of blood pressure is
known important to reduce the progression rate of renal function in patients with diabetic
renal insufficiency. We investigate the effect of blood pressure control on the progression
rate of renal function in 30 patients with diabetic renal insufficiency.
Method : We divided the observation time to 3 periods arbitarily according to degree of
blood pressure control. The progression rate of renal function was measured by the monthly
changs of serum creatinine concentration and reciprocal serum creatinine concentration.
Result : The monthly changes in serum creatinine concentration in A period (MBP 105
mmHg), B period (105 mmHg0.0797±0.0286, 0.2224±0.0976 and 0.2731±0.0452 mg/dl/month, respectively.
The monthly changes in reciprocal serum creatinine concentrations in A,B,C period were
-0.0079±0.0018,-0.0430±0.0093 and -0.0434±0.0073 dl/mg/month respectively.
The monthly changes in serum creatinine concentrations and reciprocal serum creatinine
concentrations in A period were significantly low compared with B and C periods.
Conclusion : The results may suggest that adequate control of mean blood pressure below
105 mmHg is important reduce the progression rate of renal function in patients with diabetic
renal insufficiency.
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